CLAIM CARD
Translational evidence in human populations remains limited and heterogeneous, with the single identified clinical RCT reporting null or marginal effects. Willows 2023 found that rapamycin did not mitigate age-related changes to adipose tissue or peripheral neuropathy in genetically diverse HET3 mice despite robust p-values for age-related changes themselves (P = 0.0001, P < 0.0001). This translational gap between mechanistic promise and human clinical endpoints represents a central tension in the corpus (Stanfield 2026; Chung 2019; Willows 2023).
Evidence grade: exploratory
Contradiction status: none
Publication: f02d4a53-03e5-47ed-9876-75a416e3bd24
Provenance: Derivation Web chain
Citation Support
source_1Moel 2025source_2Gkioni 2025source_3Smiaek 2023source_4Willows 2023source_5Harinath 2025