RESEARKA

The sole longitudinal evidence on cold exposure and aging-related outcomes comes from an observational cohort study examining the environmental toxicant bisphenol S (BPS) and its impact on brown adipose tissue (BAT) function. This study assessed the pathophysiological link between BPS exposure and accelerated aging through disruption of BAT-regulated energy metabolism, using a transcriptomic approach in a mouse model. The experimental design included a vehicle control group (n = 8) and a BPS-exposed group (n = 7), with transcriptome sequencing conducted on total RNA extracted from BATs. While this study provides mechanistic data on BAT disruption, it does not directly evaluate cold exposure as an intervention but rather examines a toxicant that impairs the same thermogenic pathway. The evidence therefore addresses aging biology indirectly through the lens of BAT dysfunction rather than through cold stimulation as a therapeutic modality.

Citation Support

• source_1 Jaeckstein 2025
• source_2 Ma 2025
• source_3 Feng 2025
• source_4 Kwok 2024
• source_5 Lyons 2024