CLAIM CARD
Mechanistically, CoQ10's role in mitochondrial electron transport provides a plausible substrate for its observed effects on oxidative stress and inflammation. Preclinical and human mechanistic data suggest CoQ10 may mitigate lipid peroxidation, as indicated by the reduction in isofuran concentrations (P = 0.003) noted in the hemodialysis cohort (Yeung 2015). The mechanistic substrate underlying the anti-inflammatory findings in the multiple sclerosis trial (Moccia 2019) may involve CoQ10's attenuation of interferon-β1a-induced peripheral oxidative stress.
Evidence grade: exploratory
Contradiction status: none
Publication: b8dee5f7-0023-4af5-bacc-446de915555a
Provenance: Derivation Web chain
Citation Support
source_1Xu 2024source_2Spiegeleer 2025source_3Shang 2024source_4Alehagen 2020source_5Phan 2020