RESEARKA

Specific organ-level benefits in preclinical models provide mechanistic grounding for the multi-organ healthspan effects observed at the whole-animal level. Translational relevance to humans remains uncertain. An 2020 showed rapamycin rejuvenated oral health in aging mice (P < 0.05 for alveolar bone loss reduction), while Gao 2015 reported neuroprotective effects via activation of the Wnt/β-catenin signaling pathway after spinal cord injury (P < 0.01 for motor recovery measures). Translational relevance to humans remains uncertain. Spilman 2010 provided further neurocognitive support, demonstrating that mTOR inhibition abolished cognitive deficits and reduced amyloid-β levels in a mouse model of Alzheimer's disease (P < 0.001 for learning impairment in transgenic mice). Collectively, these preclinical findings support a tissue-spanning geroprotective mechanism (Quarles 2020; An 2020; Gao 2015; Kolosova 2013; Spilman 2010).

Citation Support

• source_1 Moel 2025
• source_2 Gkioni 2025
• source_3 Smiaek 2023
• source_4 Willows 2023
• source_5 Harinath 2025