CLAIM CARD
The SAFE trial, a randomized, phase 3, double-blind, placebo-controlled trial, provided the most direct human RCT evidence within the corpus. This 2x2 factorial design evaluated the cardioprotective effects of ramipril, bisoprolol, or their combination in breast cancer patients receiving anthracycline chemotherapy.
Evidence grade: exploratory
Contradiction status: none
Publication: 9ab2e887-2e5b-429a-8d89-fd6d7813a028
Provenance: Derivation Web chain
Citation Support
source_1Lin 2026source_2Din 2026source_3Spiegeleer 2025source_4Shen 2025source_5Bene 2025