CLAIM CARD
Preclinical data from Keller 2019 suggest that enalapril treatment attenuated the development of frailty in aging mice. The study also reported differential modification of pro- and anti-inflammatory cytokines between male and female animals. However, no p-values or effect sizes were provided in the available excerpts to quantify these changes. The effect direction for the overall frailty outcome was classified as unclear due to the limited mechanistic focus.
Evidence grade: exploratory
Contradiction status: none
Publication: 9ab2e887-2e5b-429a-8d89-fd6d7813a028
Provenance: Derivation Web chain
Citation Support
source_1Lin 2026source_2Din 2026source_3Spiegeleer 2025source_4Shen 2025source_5Bene 2025