RESEARKA

Metformin's clinical effects are stratified by disease pathology and acuity, as shown by its selective survival benefit in WHO grade III but not grade IV glioma and its consistent mortality reduction in acute sepsis and COVID-19, suggesting context-dependent mechanisms that challenge uniform therapeutic application.

Citation Support

• source_1 Use of metformin and survival of patients with high‐grade glioma
• source_2 Metformin in elderly type 2 diabetes mellitus: dose-dependent dementia risk reduction
• source_3 Association Between Preadmission Metformin Use and Outcomes in Intensive Care Unit Patients With Sepsis and Type 2 Diabetes: A Cohort Study
• source_4 Metformin in the prevention of hepatocellular carcinoma in diabetic patients: A systematic review
• source_5 Metformin in Patients With COVID-19: A Systematic Review and Meta-Analysis