RESEARKA

A significant within-corpus tension exists regarding aspirin's net benefit profile. While several analyses report null findings for aspirin-based regimens compared to alternatives in specific endpoints (Saeed 2026; Stirum 2026; Hou 2026), other data suggest potential harm. For instance, a study on pregnant individuals with increased heat exposure demonstrated that aspirin use was associated with a negative effect direction on preterm birth risk, presenting a potential adverse pathway that could counter any theoretical geroprotective benefits in susceptible subpopulations (Meltzer 2026). This disagreement underscores that the overall risk-benefit calculus for aspirin as a geroprotector is not straightforward and may be modulated by environmental and individual risk factors not typically considered in aging research.

Citation Support

• source_1 Flensted-Jensen 2025
• source_2 Saeed 2026
• source_3 Zhu 2026
• source_4 Navarese 2026
• source_5 Yan 2024