CLAIM CARD
Mechanistically, the substrate for these cognitive findings may involve ACE inhibitor effects on cerebral microvascular function and endothelial health, processes that deteriorate with vascular aging. This theoretical basis is further supported by a systematic review linking methylarginine levels, modulators of nitric oxide synthesis, to vascular aging, although direct evidence for ACE inhibitor modulation of this pathway in humans remains sparse (Carmo 2025).
Evidence grade: exploratory
Contradiction status: none
Publication: 9ab2e887-2e5b-429a-8d89-fd6d7813a028
Provenance: Derivation Web chain
Citation Support
source_1Lin 2026source_2Din 2026source_3Spiegeleer 2025source_4Shen 2025source_5Bene 2025