CLAIM CARD
Quantitative findings from these studies present a profile of mixed significance and null effects. Preclinically, the mouse study by Xie et al. (2023) identified CXCL13 as an elevated chemokine in brown adipose tissue in response to cold and reported multiple statistically significant findings across its experimental analyses, with p-values ranging from P < 0.05 to P < 0.001. These data indicate that while the preclinical signal for a cold-induced, anti-inflammatory pathway in adipose tissue is robust, the translation to a measurable clinical anti-inflammatory effect in the human cohort studied was inconsistent.
Evidence grade: exploratory
Contradiction status: none
Publication: 5e04142b-5106-4483-8db7-d9378c53fb19
Provenance: Derivation Web chain
Citation Support
source_1Jaeckstein 2025source_2Ma 2025source_3Feng 2025source_4Kwok 2024source_5Lyons 2024