CLAIM CARD
Mechanistically, the work by Feng et al. (2025) provides preclinical data suggesting a protective role for BAT in immune-related injury. Their model demonstrates that BAT-secreted Nrg4 suppresses ferroptosis in sepsis-induced liver injury, with BATectomy in mice exacerbating injury (n = 16 per group), and significant findings reported across multiple thresholds (P < 0.05, P < 0.01, P < 0.001). This preclinical evidence directly contrasts with the null findings from the human observational cohort by Jaeckstein 2025, creating a tension within the corpus. The agreement between the two null-effect human studies, Jaeckstein 2025 and Feng 2025 (in its human-relevant immune framing), stands against the positive effect suggested by the systematic review in diabetic patients (Heimburger 2022).
Evidence grade: exploratory
Contradiction status: none
Publication: 5e04142b-5106-4483-8db7-d9378c53fb19
Provenance: Derivation Web chain
Citation Support
source_1Jaeckstein 2025source_2Ma 2025source_3Feng 2025source_4Kwok 2024source_5Lyons 2024