CLAIM CARD
The evidence base for ACE inhibitor effects on immune outcomes is derived from two distinct study types with no direct human trials on aging-specific endpoints. An observational cohort study by Shen and colleagues examined the association between food allergen sensitization and early vascular aging (EVA) in adults. This study identified that sensitization to at least one common food allergen was associated with an increased risk of EVA, with an odds ratio (OR) of 1.91 (95% confidence interval [CI], 1.1 to 3.3). The population studied were adults, and the study did not directly assess ACE inhibitor use, providing only contextual, indirect evidence.
Evidence grade: exploratory
Contradiction status: none
Publication: 9ab2e887-2e5b-429a-8d89-fd6d7813a028
Provenance: Derivation Web chain
Citation Support
source_1Lin 2026source_2Din 2026source_3Spiegeleer 2025source_4Shen 2025source_5Bene 2025