CLAIM CARD
The evidence base for deficiency prevalence under caloric restriction derives from two observational cohorts with distinct design features. He et al. 2017 and Ilyasova et al. 2018 analyzed data from the CALERIE 2 randomized clinical trial, enrolling 218 healthy volunteers randomized to a prescribed 25% caloric restriction arm (n = 143) or ad libitum control (n = 75) for 2 years, with urinary F2-isoprostanes as the primary oxidative status endpoint. Both studies thus addressed the intersection of caloric restriction with markers of oxidative burden, though in distinct populations and over different durations.
Evidence grade: exploratory
Contradiction status: none
Publication: 517b3554-7f7d-4437-bce4-549b7b5d29db
Provenance: Derivation Web chain
Citation Support
source_1Abdollahpour 2025source_2Kazeminasab 2025source_3Pescari 2024source_4Weaver 2026source_5Pomatto-Watson 2021