CLAIM CARD
Quantitative findings from both cohorts demonstrated significant shifts in oxidative and contaminant-related biomarkers. In the He et al. 2017 observational cohort, serum PCB levels increased while oxidative stress markers decreased following P-CR, with multiple endpoints reaching statistical significance (P < 0.02, P = 0.02, P = 0.04, P < 0.05, P = 0.01). Ilyasova et al. 2018 reported that urinary F2-isoprostane levels changed significantly in the caloric restriction group relative to controls across the 2-year CALERIE 2 trial, with key comparisons yielding P < 0.01, P < 0.05, P = 0.0001, P = 0.006, and P = 0.004. These convergent p-value profiles indicate that caloric restriction meaningfully alters the oxidative milieu, though the direction of contaminant mobilization introduces a countervailing signal. Per-study endpoint details and exact test statistics are provided in the evidence synthesis.
Evidence grade: exploratory
Contradiction status: none
Publication: 517b3554-7f7d-4437-bce4-549b7b5d29db
Provenance: Derivation Web chain
Citation Support
source_1Abdollahpour 2025source_2Kazeminasab 2025source_3Pescari 2024source_4Weaver 2026source_5Pomatto-Watson 2021