CLAIM CARD
Preclinical and mechanistic human studies provide further biological context. Velingkaar and colleagues showed that two-meal caloric restriction induced 12-hour rhythms and improved glucose homeostasis in a rodent model (P < 0.05 for glucose measures), suggesting that meal timing itself contributes to restriction-related benefits (Velingkaar 2021). These preclinical data collectively suggest that caloric restriction engages conserved molecular pathways across species, though translation to human aging outcomes remains incompletely demonstrated.
Evidence grade: exploratory
Contradiction status: none
Publication: 517b3554-7f7d-4437-bce4-549b7b5d29db
Provenance: Derivation Web chain
Citation Support
source_1Abdollahpour 2025source_2Kazeminasab 2025source_3Pescari 2024source_4Weaver 2026source_5Pomatto-Watson 2021