CLAIM CARD
Quantitative findings across these cohorts show predominantly null or mixed effects on frailty-related endpoints. Justice 2021 found that geroscience biomarker changes reached p≤0.05 in the caloric restriction arm, but these biochemical shifts did not translate into clear frailty-relevant clinical improvement. Liu 2021b reported no quantitative effect sizes, instead framing CR as a potential strategy to delay frailty onset based on mechanistic reasoning.
Evidence grade: exploratory
Contradiction status: none
Publication: 517b3554-7f7d-4437-bce4-549b7b5d29db
Provenance: Derivation Web chain
Citation Support
source_1Abdollahpour 2025source_2Kazeminasab 2025source_3Pescari 2024source_4Weaver 2026source_5Pomatto-Watson 2021