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Telomere length emerges as a dualistic biomarker where elongation simultaneously lowers cardiovascular risk but elevates cancer susceptibility, with the magnitude of these effects critically modulated by genetic variants, measurement precision, and disease-specific contexts like pulmonary fibrosis.

Evidence grade: exploratory

Contradiction status: none

Publication: a333cf41-09e0-46b6-8b35-0a83469ca23b

Provenance: Derivation Web chain

Citation Support

  • source_1 Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants
  • source_2 The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies
  • source_3 **Topic:** `telomere`
  • source_4 **Author:** Dom Lynch
  • source_5 **ORCID:** _not configured_

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