CLAIM CARD
Quantitative synthesis from Zhang (2026) provides pooled effect estimates supporting CoQ10 efficacy in metabolic disorders. Specifically, CoQ10 significantly reduced hemoglobin A1c by a weighted mean difference (WMD) of -0.22% (95% CI: -0.37, -0.06; P = 0.006) and fasting glucose by WMD = -10.07 mg/dL. Additional meta-analytic outcomes achieved conventional significance at P = 0.001, P = 0.003, and P = 0.013. By contrast, Spiegeleer (2025) observed that statin use in older adults was associated with a lower gait speed reserve (GSR) compared to non-use (-1.9 cm/s [95% CI, -3.1 to -0.72]), yielding P < 0.001 for the primary comparison and additional p-values of 0.002, 0.024, 0.034, and 0.267 for secondary analyses.
Evidence grade: exploratory
Contradiction status: none
Publication: b8dee5f7-0023-4af5-bacc-446de915555a
Provenance: Derivation Web chain
Citation Support
source_1Xu 2024source_2Spiegeleer 2025source_3Shang 2024source_4Alehagen 2020source_5Phan 2020