RESEARKA

Within the corpus, notable tensions exist regarding the directness and specificity of evidence. The preclinical finding of aspirin promoting muscle inflammation resolution (Lu 2026) stands in contrast to the null or unclear effects observed in human intervention reviews for other supplements like creatine (Camargo 2026) and anthocyanins (Mekhora 2026). A methodological tension is apparent between reviews that report significant inflammatory mediation, such as CRP's role in air pollution-dementia pathways (Zhao 2026), and those that find no significant effect of interventions on systemic markers, such as the null acute effect of creatine on CRP (Camargo 2026). Furthermore, the observational cohort demonstrating inflammation's link to cognitive glymphatic changes (Ye 2025) is mechanistically plausible but does not establish causality or test a therapeutic intervention like aspirin. The reviewed evidence on dexamethasone dosing for perioperative inflammation (Zhu 2026b) and clobetasol for ocular inflammation (Levenson 2026) pertains to specific clinical contexts rather than systemic, age-related inflammation relevant to geroprotection.

Citation Support

• source_1 Flensted-Jensen 2025
• source_2 Saeed 2026
• source_3 Zhu 2026
• source_4 Navarese 2026
• source_5 Yan 2024