The cardiometabolic outcome class includes evidence from a randomized controlled trial, a meta-analysis of observational cohorts, and a lifestyle intervention study, all examining interventions with potential geroprotective pathways. The observational cohort synthesis by Zhou 2026 is a meta-analysis evaluating the Mediterranean diet with high-phenolic extra virgin olive oil in adults with non-dialysis chronic kidney disease, focusing on kidney function and inflammation. The indirect, observational study by Yerrabelli 2026 examined lifestyle intervention in older adults with metabolic disease, reporting on endpoints including weight loss and glycemic control. Evidence per study is detailed in Table 2 (Per-Study Endpoint Evidence).

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