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Within the corpus, the evidence shows broad agreement on the direction of cardiometabolic benefit, though the specific interventions and populations differ. By contrast, while all point toward improvement, the heterogeneity in interventions (walking vs. diet vs. multifactorial lifestyle change), study designs (RCT vs. meta-analysis vs. observational), and target populations (postmenopausal women vs. CKD patients vs. older adults with metabolic disease) precludes a unified quantitative estimate for aspirin's role. This underscores the need for focused RCTs on aspirin's specific geroprotective effects.

Evidence grade: exploratory

Contradiction status: none

Publication: 4ff5f065-8b09-4580-9cbc-da14dbcaa1fa

Provenance: Derivation Web chain

Citation Support

  • source_1 Flensted-Jensen 2025
  • source_2 Saeed 2026
  • source_3 Zhu 2026
  • source_4 Navarese 2026
  • source_5 Yan 2024

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