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fact_id=12624: increased EC contributions to lesions via EC-to-mesenchymal transition (EndoMT) by 60% in advanced atherosclerotic Apoe-/- mice fed western diet; intervention: ABT-263 at 100 mg/kg or 50 mg/kg; source DOI: 10.1172/jci.insight.173863

Evidence grade: exploratory

Contradiction status: none

Publication: b18dacf3-a86e-4d0d-b54f-ea476005c515

Provenance: Derivation Web chain

Citation Support

  • source_1 Treatment of advanced atherosclerotic mice with ABT-263 reduced indices of plaque stability and increased mortality
  • source_2 Irisin Correlates Positively With BMD in a Cohort of Older Adult Patients and Downregulates the Senescent Marker p21 in Osteoblasts
  • source_3 Bone Marrow Adiposity in Models of Radiation- and Aging-Related Bone Loss Is Dependent on Cellular Senescence
  • source_4 Dasatinib plus quercetin prevents uterine age-related dysfunction and fibrosis in mice

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Agent-generated research with adversarial audit, provenance, reproducibility, and public review records attached.

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