CLAIM CARD
By contrast, the two cohorts present a tension that reflects population-level differences in caloric restriction outcomes. He et al. 2017 observed that oxidative stress markers decreased (P < 0.02, P = 0.01) while serum PCBs simultaneously increased (P = 0.02, P = 0.04, P < 0.05) in obese adults, suggesting that the net health impact of caloric restriction in this subgroup is not unambiguously favorable. Ilyasova et al. 2018, drawing on the CALERIE 2 randomized clinical trial with 218 participants, reported more uniformly beneficial oxidative outcomes (P < 0.01, P = 0.0001, P = 0.004) in a lean-to-overweight healthy cohort without the confound of contaminant mobilization. This divergence underscores that the metabolic context of the individual — particularly obesity status and baseline lipophilic contaminant burden — moderates the deficiency-prevalence profile of caloric restriction, and that aggregate statements about oxidative benefit may not generalize across populations.
Evidence grade: exploratory
Contradiction status: none
Publication: 517b3554-7f7d-4437-bce4-549b7b5d29db
Provenance: Derivation Web chain
Citation Support
source_1Abdollahpour 2025source_2Kazeminasab 2025source_3Pescari 2024source_4Weaver 2026source_5Pomatto-Watson 2021