RESEARKA

Within the corpus, the evidence for this outcome class stems primarily from this single observational cohort, introducing a tension between the strength of the statistical signals and the directness of the study design. The significant p-values indicate a clear association, yet the indirect nature of the evidence—linking CGM-derived variability to infection-related inflammation rather than measuring a direct immune aging endpoint—limits causal inference. This creates a gap where mechanistic plausibility is supported, but definitive human-RCT evidence establishing glucose variability as a modulator of immunosenescence remains sparse.

Citation Support

• source_1 Sidki 2026
• source_2 Gravesteijn 2023
• source_3 Lu 2021
• source_4 Lee 2020
• source_5 Franceschi 2026