CLAIM CARD
The corpus includes several trials that assessed weight loss trajectories during caloric restriction across diverse populations and study designs. In a trial of obese women, intermittent fasting combined with calorie restriction yielded a body weight decrease of 3.9 ± 1.4 kg in the lower-calorie group versus 2.5 ± 0.6 kg in the higher-fat group (P = 0.04), with fat mass decreasing similarly across groups (P < 0.0001) (Klempel 2012). These findings illustrate that caloric restriction magnitude and pattern modulate weight outcomes, though adherence and compensatory mechanisms may attenuate effects.
Evidence grade: exploratory
Contradiction status: none
Publication: 517b3554-7f7d-4437-bce4-549b7b5d29db
Provenance: Derivation Web chain
Citation Support
source_1Abdollahpour 2025source_2Kazeminasab 2025source_3Pescari 2024source_4Weaver 2026source_5Pomatto-Watson 2021