CLAIM CARD
Mechanistically, the attenuation of frailty in the mouse model is proposed to involve modulation of the renin-angiotensin system and associated inflammatory pathways. Keller 2019 specifically noted differential cytokine responses, suggesting a biological basis for the observed functional changes. This provides theoretical plausibility for a role of ACE inhibitors in age-related frailty, but the pathway has not been validated in human clinical populations.
Evidence grade: exploratory
Contradiction status: none
Publication: 9ab2e887-2e5b-429a-8d89-fd6d7813a028
Provenance: Derivation Web chain
Citation Support
source_1Lin 2026source_2Din 2026source_3Spiegeleer 2025source_4Shen 2025source_5Bene 2025