CLAIM CARD
Mechanistic preclinical evidence provides foundational insights into dose-response relationships relevant to brown adipose tissue (BAT) biology. Sarmiento-Ortega et al. (2025) examined the effects of minimal risk doses of cadmium exposure on BAT histological and functional alterations in a controlled Wistar rat model. The study design included a control group (n = 30) with access to cadmium-free water and experimental groups (n = 60) subdivided into two subgroups receiving defined cadmium doses. This preclinical framework allows for the systematic assessment of dose-dependent pathological changes in BAT, providing a translational basis for understanding toxicological thresholds. The work underscores the importance of precise dosimetry in animal models to establish the boundaries between physiological stressors and pathological insults to thermogenic adipose tissue.
Evidence grade: exploratory
Contradiction status: none
Publication: 5e04142b-5106-4483-8db7-d9378c53fb19
Provenance: Derivation Web chain
Citation Support
source_1Jaeckstein 2025source_2Ma 2025source_3Feng 2025source_4Kwok 2024source_5Lyons 2024