CLAIM CARD
Mechanistically, the renal protective effects observed in cardiac surgery may be mediated through modulation of intra-renal hemodynamics and reduction of inflammation, pathways relevant to age-related nephron loss (Kilic 2026). The high attrition rate observed in the Singapore cohort (Senanayake 2026) points to a mechanistic tension between the theoretical long-term benefits of ACE inhibition and the practical reality of patient tolerance and persistence. Furthermore, the case of lisinopril-induced hallucinations (Golder 2026) suggests a potential, if rare, effect on central neurotransmitter systems, a consideration for geriatric prescribing.
Evidence grade: exploratory
Contradiction status: none
Publication: 9ab2e887-2e5b-429a-8d89-fd6d7813a028
Provenance: Derivation Web chain
Citation Support
source_1Lin 2026source_2Din 2026source_3Spiegeleer 2025source_4Shen 2025source_5Bene 2025