RESEARKA

Useful falsification work includes independent replication in advanced plaque models, dose-response separation of smooth-muscle-cell loss from EndoMT induction, comparison with non-ABT-263 senolytics, and human vascular safety evidence. A broader review should also test whether earlier-stage plaque, lower-dose exposure, or intermittent treatment changes the direction of the risk signal.

Citation Support

• source_1 Treatment of advanced atherosclerotic mice with ABT-263 reduced indices of plaque stability and increased mortality
• source_2 Irisin Correlates Positively With BMD in a Cohort of Older Adult Patients and Downregulates the Senescent Marker p21 in Osteoblasts
• source_3 Bone Marrow Adiposity in Models of Radiation- and Aging-Related Bone Loss Is Dependent on Cellular Senescence
• source_4 Dasatinib plus quercetin prevents uterine age-related dysfunction and fibrosis in mice