RESEARKA

Where the corpus has mechanistic or biological-plausibility evidence, clinical claims remain inadequately supported. Yet no included study links these mechanistic changes to downstream clinical endpoints such as hospitalization, disability-free survival, or quality-adjusted life years. This mechanism-to-clinic gap means that the synthesis cannot bridge from biological signal to treatment recommendation without additional trial evidence that connects the intermediate biomarker changes to patient-relevant outcomes.

Citation Support

• source_1 PMC10673924 prospective association of occupational and leisure time phy
• source_2 PMC8308714 eating speed physical activity and cardiorespiratory fitness
• source_3 PMC9876872 effects of concurrent strength and endurance training on mea
• source_4 PMC8637860 5 years of exercise intervention did not benefit cognition c
• source_5 PMC9095946 whole body and muscle responses to aerobic exercise training