CLAIM CARDS
Claim Cards
Atomic claims extracted from accepted Researka artifacts, with source support, contradiction state, and provenance links when available.
Filtered to publication 002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd
exploratory
Headline:** Cardiovascular protection versus cancer risk: a Mendelian randomization and meta-analysis synthesis of telomere length effects
Contradiction: none
Sources: 5
exploratoryThe cited A/B receipts support a specific working claim: Genetically determined longer telomere length was associated with lowered risk of coronary heart disease (CHD; OR = 0.95, 95% CI: 0.92-0.98); but raised risk of cancer (OR = 1.11, 95% CI: 1.06-1.16). The cited receipts are separate evidence streams; this memo maps a testable contrast, not one integrated analysis.
Contradiction: none
Sources: 5
exploratoryInterpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication.
Contradiction: none
Sources: 5
exploratoryThe evidence exposes a paradoxical role of telomere length—cardioprotective yet carcinogenic—modulated by methodological heterogeneity and genetic background, suggesting that risk assessment must account for measurement techniques and disease-specific contexts.
Contradiction: none
Sources: 5
exploratoryKnown / obvious (do not republish): Telomere length shortens with chronological age; Shorter telomeres are associated with increased all-cause mortality risk
Contradiction: none
Sources: 5
exploratoryReal tension: Fact 109012 (lower CHD risk with longer TL) vs Fact 109013 (higher cancer risk with longer TL) in the same UK Biobank population aged 60+
Contradiction: none
Sources: 5
exploratory`fact_id=109012` (`A_core`) — Genetically determined longer telomere length was associated with lowered risk of coronary heart disease (CHD; OR = 0.95, 95% CI: 0.92-0.98) doi=10.1111/acel.13017
Contradiction: none
Sources: 5
exploratory`fact_id=109013` (`A_core`) — but raised risk of cancer (OR = 1.11, 95% CI: 1.06-1.16) doi=10.1111/acel.13017
Contradiction: none
Sources: 5
exploratory`fact_id=3475` (`A_core`) — In the comparison of the longest versus shortest third of TL, we observed a marginally positive association between longer TL and higher risk of total cancers [OR = 1.086; 95% CI, 0.952-1.238]. doi=10.1158/1055-9965.epi-16-0968
Contradiction: none
Sources: 5
exploratory_No A_core/B_context counter-evidence found in this run; treat this as a single-direction signal until a broader receipt expansion finds a real opposing fact._
Contradiction: none
Sources: 5
exploratorySuggested citation:** Dom Lynch. (2026). Cardiovascular protection versus cancer risk: a Mendelian randomization and meta-analysis synthesis of telomere length effects. ReseaRka Evidence Index. Version 1.0.
Contradiction: none
Sources: 5
exploratoryPriority note:** This memo records the first published framing, source bundle, and evidence receipts for this run. Reuse should cite the canonical version.
Contradiction: none
Sources: 5