CLAIM CARDS
Claim Cards
Atomic claims extracted from accepted Researka artifacts, with source support, contradiction state, and provenance links when available.
Filtered to publication 3b113aa9-b186-46fc-b8f4-57f813513544
exploratory
Source scope:** 16 A/B-bound receipts across 10 evidence sources; 12 total references in the source bundle. Two source-bundle entries are corpus-context references for breadth, not thesis proof; schema labels still use primary/review only.
Contradiction: none
Sources: 5
exploratoryThe exercise corpus in this run supports a broader alpha signal: exercise effects are endpoint- and context-specific rather than uniformly generalizable. The strongest bound receipts span inflammatory markers, exercise capacity and mortality, tumor-model response, angiogenesis biomarkers, muscle-protein synthesis, peripheral oxygen extraction, dietary inflammatory index, and NO/exercise muscle effects.
Contradiction: none
Sources: 5
exploratoryThe common story treats exercise as a single beneficial geroscience intervention. This evidence map says the more useful signal is specificity: different populations, endpoints, and mechanisms move differently, so the publishable claim is not “exercise works,” but “exercise signals need endpoint- and context-specific interpretation.”
Contradiction: none
Sources: 5
exploratory`fact_id=12572` (`A_core`) — Mixed-muscle protein fractional synthetic rate increased by 42% at 3 h postexercise and 69% at 24 h postexercise in CON. DOI `10.1152/ajpendo.00600.2013`
Contradiction: none
Sources: 5
exploratory`fact_id=12573` (`A_core`) — Mixed-muscle protein fractional synthetic rate increased by 42% at 3 h postexercise and 69% at 24 h postexercise in CON. DOI `10.1152/ajpendo.00600.2013`
Contradiction: none
Sources: 5
exploratory`fact_id=12544` (`A_core`) — Mortality risk was 11% lower (hazard ratio, 0.89; 95% confidence interval, 0.86-0.93; P<0.001) for every 1-MET increase in exercise capacity. DOI `10.1161/hypertensionaha.114.03510`
Contradiction: none
Sources: 5
exploratory`fact_id=30392` (`A_core`) — IGF-I/IGFBP-3 ratio increased significantly in the diet + exercise group (+5.4%, P < 0.01) compared with control. DOI `10.1158/1055-9965.epi-13-0337`
Contradiction: none
Sources: 5
exploratory`fact_id=34200` (`A_core`) — NO-donor treatment with isosorbide dinitrate for 6 wk, in combination with voluntary exercise for 3 wk, increased muscle mass by 25% DOI `10.1152/ajpcell.00305.2011`
Contradiction: none
Sources: 5
exploratory2. Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development (2017). DOI `10.1158/0008-5472.can-16-3125` — `primary`
Contradiction: none
Sources: 5
exploratory10. Nitric oxide and voluntary exercise together promote quadriceps hypertrophy and increase vascular density in female 18-mo-old mice (2012). DOI `10.1152/ajpcell.00305.2011` — `primary`
Contradiction: none
Sources: 5
exploratoryDo not treat exercise as one generic anti-aging lever in review or trial design. Split claims by endpoint family before making a broad conclusion: inflammation, tumor biology, vascular oxygenation, muscle synthesis, mortality/exercise capacity, and diet-linked biomarker changes are different evidence lanes.
Contradiction: none
Sources: 5
exploratoryThe topic is heterogeneous, so the memo should guide subtopic extraction rather than support one pooled treatment-effect claim.
Contradiction: none
Sources: 5
exploratoryNo A_core/B_context counter-evidence was classified in this run, but the heterogeneity of endpoints is itself a constraint on broad claims.
Contradiction: none
Sources: 5
exploratoryRe-run counter-evidence search against each child topic so “no counter-evidence found” is not confused with proof of absence.
Contradiction: none
Sources: 5
exploratorySuggested citation:** Dom Lynch. (2026). Exercise signals are endpoint-specific, not uniformly generalizable. ReseaRka Evidence Index. Version 1.0.
Contradiction: none
Sources: 5