CLAIM CARDS
Claim Cards
Atomic claims extracted from accepted Researka artifacts, with source support, contradiction state, and provenance links when available.
Filtered to publication a333cf41-09e0-46b6-8b35-0a83469ca23b
exploratory
Telomere length emerges as a dualistic biomarker where elongation simultaneously lowers cardiovascular risk but elevates cancer susceptibility, with the magnitude of these effects critically modulated by genetic variants, measurement precision, and disease-specific contexts like pulmonary fibrosis.
Contradiction: none
Sources: 5
exploratoryKnown / obvious (do not republish): Telomere length shortens with age; Shorter telomeres are generally associated with higher mortality risk; Telomere length is influenced by genetic factors
Contradiction: none
Sources: 5
exploratoryReal tension: Fact 1 shows genetically determined longer telomere length lowers coronary heart disease risk, while facts 4 and 7 indicate it raises cancer risk, creating a therapeutic dilemma.
Contradiction: none
Sources: 5
exploratory`fact_id=109012` (`A_core`) — Genetically determined longer telomere length was associated with lowered risk of coronary heart disease (CHD; OR = 0.95, 95% CI: 0.92-0.98) DOI `10.1111/acel.13017`
Contradiction: none
Sources: 5
exploratory`fact_id=109013` (`A_core`) — but raised risk of cancer (OR = 1.11, 95% CI: 1.06-1.16) DOI `10.1111/acel.13017`
Contradiction: none
Sources: 5
exploratory_No A_core/B_context counter-evidence found in this run; treat this as a single-direction signal until a broader receipt expansion finds a real opposing fact._
Contradiction: none
Sources: 5
exploratoryGenetically determined longer telomere length was associated with lowered risk of coronary heart disease (CHD; OR = 0.95, 95% CI: 0.92-0.98) _(alpha cues: translation_context)_
Contradiction: none
Sources: 5
exploratorySuggested citation:** Dom Lynch. (2026). The Telomere Length Paradox: Quantifying Trade-offs Between Cardioprotection and Carcinogenesis Across Subgroups. ReseaRka Evidence Index. Version 1.0.
Contradiction: none
Sources: 5
exploratoryPriority note:** This memo records the first published framing, source bundle, and evidence receipts for this run. Reuse should cite the canonical version.
Contradiction: none
Sources: 5