{"publication_id":"002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd","traces":[{"claim_id":"claim_1","claim":"Headline:** Cardiovascular protection versus cancer risk: a Mendelian randomization and meta-analysis synthesis of telomere length effects","candidate_sources":[{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis","doi":"10.1164/rccm.201902-0360oc","url":null},{"study":"Telomere Length and All-Cause Mortality: A Meta-analysis","doi":"10.1016/j.arr.2018.09.002","url":null},{"study":"Telomere length and brain aging: A systematic review and meta-analysis","doi":"10.1016/j.arr.2022.101679","url":null}]},{"claim_id":"claim_2","claim":"The cited A/B receipts support a specific working claim: Genetically determined longer telomere length was associated with lowered risk of coronary heart disease (CHD; OR = 0.95, 95% CI: 0.92-0.98); but raised risk of cancer (OR = 1.11, 95% CI: 1.06-1.16). The cited receipts are separate evidence streams; this memo maps a testable contrast, not one integrated analysis.","candidate_sources":[{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis","doi":"10.1164/rccm.201902-0360oc","url":null},{"study":"Telomere Length and All-Cause Mortality: A Meta-analysis","doi":"10.1016/j.arr.2018.09.002","url":null},{"study":"Telomere length and brain aging: A systematic review and meta-analysis","doi":"10.1016/j.arr.2022.101679","url":null}]},{"claim_id":"claim_3","claim":"Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication.","candidate_sources":[{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis","doi":"10.1164/rccm.201902-0360oc","url":null},{"study":"Telomere Length and All-Cause Mortality: A Meta-analysis","doi":"10.1016/j.arr.2018.09.002","url":null},{"study":"Telomere length and brain aging: A systematic review and meta-analysis","doi":"10.1016/j.arr.2022.101679","url":null}]},{"claim_id":"claim_4","claim":"The evidence exposes a paradoxical role of telomere length—cardioprotective yet carcinogenic—modulated by methodological heterogeneity and genetic background, suggesting that risk assessment must account for measurement techniques and disease-specific contexts.","candidate_sources":[{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis","doi":"10.1164/rccm.201902-0360oc","url":null},{"study":"Telomere Length and All-Cause Mortality: A Meta-analysis","doi":"10.1016/j.arr.2018.09.002","url":null},{"study":"Telomere length and brain aging: A systematic review and meta-analysis","doi":"10.1016/j.arr.2022.101679","url":null}]},{"claim_id":"claim_5","claim":"Known / obvious (do not republish): Telomere length shortens with chronological age; Shorter telomeres are associated with increased all-cause mortality risk","candidate_sources":[{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis","doi":"10.1164/rccm.201902-0360oc","url":null},{"study":"Telomere Length and All-Cause Mortality: A Meta-analysis","doi":"10.1016/j.arr.2018.09.002","url":null},{"study":"Telomere length and brain aging: A systematic review and meta-analysis","doi":"10.1016/j.arr.2022.101679","url":null}]},{"claim_id":"claim_6","claim":"Real tension: Fact 109012 (lower CHD risk with longer TL) vs Fact 109013 (higher cancer risk with longer TL) in the same UK Biobank population aged 60+","candidate_sources":[{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis","doi":"10.1164/rccm.201902-0360oc","url":null},{"study":"Telomere Length and All-Cause Mortality: A Meta-analysis","doi":"10.1016/j.arr.2018.09.002","url":null},{"study":"Telomere length and brain aging: A systematic review and meta-analysis","doi":"10.1016/j.arr.2022.101679","url":null}]},{"claim_id":"claim_7","claim":"`fact_id=109012` (`A_core`) — Genetically determined longer telomere length was associated with lowered risk of coronary heart disease (CHD; OR = 0.95, 95% CI: 0.92-0.98) doi=10.1111/acel.13017","candidate_sources":[{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis","doi":"10.1164/rccm.201902-0360oc","url":null},{"study":"Telomere Length and All-Cause Mortality: A Meta-analysis","doi":"10.1016/j.arr.2018.09.002","url":null},{"study":"Telomere length and brain aging: A systematic review and meta-analysis","doi":"10.1016/j.arr.2022.101679","url":null}]},{"claim_id":"claim_8","claim":"`fact_id=109013` (`A_core`) — but raised risk of cancer (OR = 1.11, 95% CI: 1.06-1.16) doi=10.1111/acel.13017","candidate_sources":[{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis","doi":"10.1164/rccm.201902-0360oc","url":null},{"study":"Telomere Length and All-Cause Mortality: A Meta-analysis","doi":"10.1016/j.arr.2018.09.002","url":null},{"study":"Telomere length and brain aging: A systematic review and meta-analysis","doi":"10.1016/j.arr.2022.101679","url":null}]},{"claim_id":"claim_9","claim":"`fact_id=3475` (`A_core`) — In the comparison of the longest versus shortest third of TL, we observed a marginally positive association between longer TL and higher risk of total cancers [OR = 1.086; 95% CI, 0.952-1.238]. doi=10.1158/1055-9965.epi-16-0968","candidate_sources":[{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis","doi":"10.1164/rccm.201902-0360oc","url":null},{"study":"Telomere Length and All-Cause Mortality: A Meta-analysis","doi":"10.1016/j.arr.2018.09.002","url":null},{"study":"Telomere length and brain aging: A systematic review and meta-analysis","doi":"10.1016/j.arr.2022.101679","url":null}]},{"claim_id":"claim_10","claim":"_No A_core/B_context counter-evidence found in this run; treat this as a single-direction signal until a broader receipt expansion finds a real opposing fact._","candidate_sources":[{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis","doi":"10.1164/rccm.201902-0360oc","url":null},{"study":"Telomere Length and All-Cause Mortality: A Meta-analysis","doi":"10.1016/j.arr.2018.09.002","url":null},{"study":"Telomere length and brain aging: A systematic review and meta-analysis","doi":"10.1016/j.arr.2022.101679","url":null}]},{"claim_id":"claim_11","claim":"Suggested citation:** Dom Lynch. (2026). Cardiovascular protection versus cancer risk: a Mendelian randomization and meta-analysis synthesis of telomere length effects. ReseaRka Evidence Index. Version 1.0.","candidate_sources":[{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis","doi":"10.1164/rccm.201902-0360oc","url":null},{"study":"Telomere Length and All-Cause Mortality: A Meta-analysis","doi":"10.1016/j.arr.2018.09.002","url":null},{"study":"Telomere length and brain aging: A systematic review and meta-analysis","doi":"10.1016/j.arr.2022.101679","url":null}]},{"claim_id":"claim_12","claim":"Priority note:** This memo records the first published framing, source bundle, and evidence receipts for this run. Reuse should cite the canonical version.","candidate_sources":[{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis","doi":"10.1164/rccm.201902-0360oc","url":null},{"study":"Telomere Length and All-Cause Mortality: A Meta-analysis","doi":"10.1016/j.arr.2018.09.002","url":null},{"study":"Telomere length and brain aging: A systematic review and meta-analysis","doi":"10.1016/j.arr.2022.101679","url":null}]}]}