{"publication_id":"002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd","content_hash":"sha256:6a30e0296b0742690e712fec2a1767acf70963de0db0cc7ce7ed2f4bae35abf9","nodes":[{"id":"002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd","type":"publication","title":"Cardiovascular protection versus cancer risk: a Mendelian randomization and meta-analysis synthesis of telomere length effects"},{"id":"claim_1","type":"claim","text":"Headline:** Cardiovascular protection versus cancer risk: a Mendelian randomization and meta-analysis synthesis of telomere length effects"},{"id":"claim_2","type":"claim","text":"The cited A/B receipts support a specific working claim: Genetically determined longer telomere length was associated with lowered risk of coronary heart disease (CHD; OR = 0.95, 95% CI: 0.92-0.98); but raised risk of cancer (OR = 1.11, 95% CI: 1.06-1.16). The cited receipts are separate evidence streams; this memo maps a testable contrast, not one integrated analysis."},{"id":"claim_3","type":"claim","text":"Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication."},{"id":"claim_4","type":"claim","text":"The evidence exposes a paradoxical role of telomere length—cardioprotective yet carcinogenic—modulated by methodological heterogeneity and genetic background, suggesting that risk assessment must account for measurement techniques and disease-specific contexts."},{"id":"claim_5","type":"claim","text":"Known / obvious (do not republish): Telomere length shortens with chronological age; Shorter telomeres are associated with increased all-cause mortality risk"},{"id":"claim_6","type":"claim","text":"Real tension: Fact 109012 (lower CHD risk with longer TL) vs Fact 109013 (higher cancer risk with longer TL) in the same UK Biobank population aged 60+"},{"id":"claim_7","type":"claim","text":"`fact_id=109012` (`A_core`) — Genetically determined longer telomere length was associated with lowered risk of coronary heart disease (CHD; OR = 0.95, 95% CI: 0.92-0.98) doi=10.1111/acel.13017"},{"id":"claim_8","type":"claim","text":"`fact_id=109013` (`A_core`) — but raised risk of cancer (OR = 1.11, 95% CI: 1.06-1.16) doi=10.1111/acel.13017"},{"id":"claim_9","type":"claim","text":"`fact_id=3475` (`A_core`) — In the comparison of the longest versus shortest third of TL, we observed a marginally positive association between longer TL and higher risk of total cancers [OR = 1.086; 95% CI, 0.952-1.238]. doi=10.1158/1055-9965.epi-16-0968"},{"id":"claim_10","type":"claim","text":"_No A_core/B_context counter-evidence found in this run; treat this as a single-direction signal until a broader receipt expansion finds a real opposing fact._"},{"id":"claim_11","type":"claim","text":"Suggested citation:** Dom Lynch. (2026). Cardiovascular protection versus cancer risk: a Mendelian randomization and meta-analysis synthesis of telomere length effects. ReseaRka Evidence Index. Version 1.0."},{"id":"claim_12","type":"claim","text":"Priority note:** This memo records the first published framing, source bundle, and evidence receipts for this run. Reuse should cite the canonical version."},{"id":"source_1","type":"source","study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","year":2019,"doi":"10.1111/acel.13017","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_2","type":"source","study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","year":2017,"doi":"10.1158/1055-9965.epi-16-0968","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_3","type":"source","study":"Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis","year":2019,"doi":"10.1164/rccm.201902-0360oc","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_4","type":"source","study":"Telomere Length and All-Cause Mortality: A Meta-analysis","year":2018,"doi":"10.1016/j.arr.2018.09.002","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_5","type":"source","study":"Telomere length and brain aging: A systematic review and meta-analysis","year":2022,"doi":"10.1016/j.arr.2022.101679","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_6","type":"source","study":"**Topic:** `telomere`","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_7","type":"source","study":"**Author:** Dom Lynch","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_8","type":"source","study":"**ORCID:** _not configured_","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_9","type":"source","study":"**Version:** 1.0","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_10","type":"source","study":"**License:** CC BY-NC 4.0","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_11","type":"source","study":"**Canonical URL:** _not assigned_","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_12","type":"source","study":"**Suggested citation:** Dom Lynch. (2026). Cardiovascular protection versus cancer risk: a Mendelian randomization and meta-analysis synthesis of telomere length effects. ReseaRka Evidence Index. Version 1.0.","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_13","type":"source","study":"**Run bundle SHA-256:** `f87d32bf6f8024c7c1786fe09d30916f479b7ad4aca236ffc5ac42b88539b95c`","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_14","type":"source","study":"**Memo SHA-256:** `f1f71321d545b30354457fc320f7134991a8f498ff2c6db93ce7f3bed6b1e00e`","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_15","type":"source","study":"**Priority note:** This memo records the first published framing, source bundle, and evidence receipts for this run. Reuse should cite the canonical version.","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"}],"edges":[{"from":"002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd","to":"claim_1","type":"contains_claim"},{"from":"002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd","to":"claim_2","type":"contains_claim"},{"from":"002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd","to":"claim_3","type":"contains_claim"},{"from":"002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd","to":"claim_4","type":"contains_claim"},{"from":"002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd","to":"claim_5","type":"contains_claim"},{"from":"002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd","to":"claim_6","type":"contains_claim"},{"from":"002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd","to":"claim_7","type":"contains_claim"},{"from":"002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd","to":"claim_8","type":"contains_claim"},{"from":"002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd","to":"claim_9","type":"contains_claim"},{"from":"002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd","to":"claim_10","type":"contains_claim"},{"from":"002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd","to":"claim_11","type":"contains_claim"},{"from":"002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd","to":"claim_12","type":"contains_claim"}],"screening":{"identified":5,"screened":5,"excluded":0,"included":5,"included_or_retained":5,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"5 candidate receipts retained after source retrieval, deduplication, and topic filtering. 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