{"publication_id":"3b113aa9-b186-46fc-b8f4-57f813513544","content_hash":"sha256:dc57e138d6cb05cd05ea9bcec40aa7d5c57cf42fb56dc237eb9060f46adc1a2b","nodes":[{"id":"3b113aa9-b186-46fc-b8f4-57f813513544","type":"publication","title":"Exercise signals are endpoint-specific, not uniformly generalizable"},{"id":"claim_1","type":"claim","text":"Source scope:** 16 A/B-bound receipts across 10 evidence sources; 12 total references in the source bundle. Two source-bundle entries are corpus-context references for breadth, not thesis proof; schema labels still use primary/review only."},{"id":"claim_2","type":"claim","text":"The exercise corpus in this run supports a broader alpha signal: exercise effects are endpoint- and context-specific rather than uniformly generalizable. The strongest bound receipts span inflammatory markers, exercise capacity and mortality, tumor-model response, angiogenesis biomarkers, muscle-protein synthesis, peripheral oxygen extraction, dietary inflammatory index, and NO/exercise muscle effects."},{"id":"claim_3","type":"claim","text":"The common story treats exercise as a single beneficial geroscience intervention. This evidence map says the more useful signal is specificity: different populations, endpoints, and mechanisms move differently, so the publishable claim is not “exercise works,” but “exercise signals need endpoint- and context-specific interpretation.”"},{"id":"claim_4","type":"claim","text":"`fact_id=12572` (`A_core`) — Mixed-muscle protein fractional synthetic rate increased by 42% at 3 h postexercise and 69% at 24 h postexercise in CON. DOI `10.1152/ajpendo.00600.2013`"},{"id":"claim_5","type":"claim","text":"`fact_id=12573` (`A_core`) — Mixed-muscle protein fractional synthetic rate increased by 42% at 3 h postexercise and 69% at 24 h postexercise in CON. DOI `10.1152/ajpendo.00600.2013`"},{"id":"claim_6","type":"claim","text":"`fact_id=12544` (`A_core`) — Mortality risk was 11% lower (hazard ratio, 0.89; 95% confidence interval, 0.86-0.93; P<0.001) for every 1-MET increase in exercise capacity. DOI `10.1161/hypertensionaha.114.03510`"},{"id":"claim_7","type":"claim","text":"`fact_id=30392` (`A_core`) — IGF-I/IGFBP-3 ratio increased significantly in the diet + exercise group (+5.4%, P < 0.01) compared with control. DOI `10.1158/1055-9965.epi-13-0337`"},{"id":"claim_8","type":"claim","text":"`fact_id=34200` (`A_core`) — NO-donor treatment with isosorbide dinitrate for 6 wk, in combination with voluntary exercise for 3 wk, increased muscle mass by 25% DOI `10.1152/ajpcell.00305.2011`"},{"id":"claim_9","type":"claim","text":"2. Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development (2017). DOI `10.1158/0008-5472.can-16-3125` — `primary`"},{"id":"claim_10","type":"claim","text":"10. Nitric oxide and voluntary exercise together promote quadriceps hypertrophy and increase vascular density in female 18-mo-old mice (2012). DOI `10.1152/ajpcell.00305.2011` — `primary`"},{"id":"claim_11","type":"claim","text":"Do not treat exercise as one generic anti-aging lever in review or trial design. Split claims by endpoint family before making a broad conclusion: inflammation, tumor biology, vascular oxygenation, muscle synthesis, mortality/exercise capacity, and diet-linked biomarker changes are different evidence lanes."},{"id":"claim_12","type":"claim","text":"The topic is heterogeneous, so the memo should guide subtopic extraction rather than support one pooled treatment-effect claim."},{"id":"claim_13","type":"claim","text":"No A_core/B_context counter-evidence was classified in this run, but the heterogeneity of endpoints is itself a constraint on broad claims."},{"id":"claim_14","type":"claim","text":"Re-run counter-evidence search against each child topic so “no counter-evidence found” is not confused with proof of absence."},{"id":"claim_15","type":"claim","text":"Suggested citation:** Dom Lynch. (2026). Exercise signals are endpoint-specific, not uniformly generalizable. ReseaRka Evidence Index. Version 1.0."},{"id":"source_1","type":"source","study":"Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin","year":2014,"doi":"10.1152/ajpendo.00600.2013","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_2","type":"source","study":"Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development","year":2017,"doi":"10.1158/0008-5472.can-16-3125","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_3","type":"source","study":"Exercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years","year":2014,"doi":"10.1161/hypertensionaha.114.03510","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_4","type":"source","study":"Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial","year":2020,"doi":"10.1158/1940-6207.capr-20-0188","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_5","type":"source","study":"Effects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial","year":2013,"doi":"10.1158/1055-9965.epi-13-0337","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_6","type":"source","study":"Blood pressure and calf muscle oxygen extraction during plantar flexion exercise in peripheral artery disease","year":2017,"doi":"10.1152/japplphysiol.01110.2016","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_7","type":"source","study":"Dietary Weight Loss and Exercise Effects on Serum Biomarkers of Angiogenesis in Overweight Postmenopausal Women: A Randomized Controlled Trial","year":2016,"doi":"10.1158/0008-5472.can-16-0399","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_8","type":"source","study":"Abnormal protein turnover and anabolic resistance to exercise in sarcopenic obesity","year":2013,"doi":"10.1096/fj.12-224006","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_9","type":"source","study":"Changes in Dietary Inflammatory Index Patterns with Weight Loss in Women: A Randomized Controlled Trial","year":2020,"doi":"10.1158/1940-6207.capr-20-0181","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_10","type":"source","study":"Nitric oxide and voluntary exercise together promote quadriceps hypertrophy and increase vascular density in female 18-mo-old mice","year":2012,"doi":"10.1152/ajpcell.00305.2011","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_11","type":"source","study":"Exercise training undertaken by people within 12 months of lung resection for non-small cell lung cancer","year":2019,"doi":"10.1002/14651858.cd009955.pub3","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_12","type":"source","study":"Aerobic Exercise Attenuates Frailty in Aging Male and Female C57Bl/6 Mice and Effects Systemic Cytokines Differentially by Sex","year":2021,"doi":"10.1093/gerona/glab297","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_13","type":"source","study":"**Topic:** `exercise`","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_14","type":"source","study":"**Author:** Dom Lynch","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_15","type":"source","study":"**Version:** 1.0","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_16","type":"source","study":"**License:** CC BY-NC 4.0","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_17","type":"source","study":"**Suggested citation:** Dom Lynch. (2026). Exercise signals are endpoint-specific, not uniformly generalizable. ReseaRka Evidence Index. Version 1.0.","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_18","type":"source","study":"**Run:** `exercise-evidence-2026-05-16T18-12-38Z`","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"}],"edges":[{"from":"3b113aa9-b186-46fc-b8f4-57f813513544","to":"claim_1","type":"contains_claim"},{"from":"3b113aa9-b186-46fc-b8f4-57f813513544","to":"claim_2","type":"contains_claim"},{"from":"3b113aa9-b186-46fc-b8f4-57f813513544","to":"claim_3","type":"contains_claim"},{"from":"3b113aa9-b186-46fc-b8f4-57f813513544","to":"claim_4","type":"contains_claim"},{"from":"3b113aa9-b186-46fc-b8f4-57f813513544","to":"claim_5","type":"contains_claim"},{"from":"3b113aa9-b186-46fc-b8f4-57f813513544","to":"claim_6","type":"contains_claim"},{"from":"3b113aa9-b186-46fc-b8f4-57f813513544","to":"claim_7","type":"contains_claim"},{"from":"3b113aa9-b186-46fc-b8f4-57f813513544","to":"claim_8","type":"contains_claim"},{"from":"3b113aa9-b186-46fc-b8f4-57f813513544","to":"claim_9","type":"contains_claim"},{"from":"3b113aa9-b186-46fc-b8f4-57f813513544","to":"claim_10","type":"contains_claim"},{"from":"3b113aa9-b186-46fc-b8f4-57f813513544","to":"claim_11","type":"contains_claim"},{"from":"3b113aa9-b186-46fc-b8f4-57f813513544","to":"claim_12","type":"contains_claim"},{"from":"3b113aa9-b186-46fc-b8f4-57f813513544","to":"claim_13","type":"contains_claim"},{"from":"3b113aa9-b186-46fc-b8f4-57f813513544","to":"claim_14","type":"contains_claim"},{"from":"3b113aa9-b186-46fc-b8f4-57f813513544","to":"claim_15","type":"contains_claim"}],"screening":{"identified":12,"screened":12,"excluded":0,"included":12,"included_or_retained":12,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"12 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]}}