{"publication_id":"40ee40b9-6c56-499a-8ac8-120a3efd2edf","method_note":"Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.","sources":[{"study":"Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging","doi":"10.1093/gerona/glz177","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice","doi":"10.7554/eLife.16351","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Rapamycin fed late in life extends lifespan in genetically heterogeneous mice","doi":"10.1038/nature08221","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction","doi":"10.1111/acel.12194","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer","doi":"10.1111/acel.12496","risk_of_bias":"not appraised in public sidecar","directness":"primary"}]}