{"publication_id":"798fcdb7-5e51-43e8-978e-937dfca0ad1c","screening":{"identified":36,"screened":36,"excluded":0,"included":36,"included_or_retained":36,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"36 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]},"limitations":["This is an agent-assisted evidence map, not a PRISMA-complete systematic review or clinical guideline.","It is not PROSPERO-registered and should not be read as medical advice.","Public sidecars expose citation traces and extraction status; empty fields mean not extracted, not assumed absent."],"contradictions":["Evidence-honesty note: 24/36 retained sources are indirect, review-level, adjacent, or mechanistic and are used only to bound interpretation. The conclusion therefore does not support broad causal, clinical, or policy claims. This synthesis tests the thesis that evidence for Calcium Supplementation Effects is context-dependent, separating outcome-specific signals from broader claims and identifying the evidence gaps that should bound interpretation. Calcium supplementation has long been proposed as a low-cost public-health lever for bone, cardiovascular, and pregnancy-related outcomes, yet contemporary evidence has been complicated by discrepant findings across indications, populations, and dosing regimens. We conducted an AI-assisted structured evidence synthesis across the curated source set, applying a transparent audit trail in which each study was tagged for design, directness, outcome class, and direction of effect before integration.","Calcium supplementation has long been proposed as a low-cost public-health lever for bone, cardiovascular, and pregnancy-related outcomes, yet contemporary evidence has been complicated by discrepant findings across indications, populations, and dosing regimens.","Across the corpus, the evidence base is context-dependent rather than uniformly favorable: pre-eclampsia prevention, certain insulin-related endpoints, and selected bone-fracture outcomes show benefit, while older-adult and pregnancy inflammation biomarkers, recurrent cardiovascular events, and several body-composition endpoints remain null or unfavorable, with mechanistic plausibility (Ioannidis 2005) coexisting alongside sparse or mixed human-RCT confirmation.","We conclude that calcium supplementation should not be framed as a monolithic intervention: the most defensible indications remain high-risk pregnancy, while bone-fracture benefit in community-dwelling older adults and cardiovascular safety in at-risk populations remain insufficiently resolved and warrant further direct, outcome-stratified randomized evaluation.","Direction reconciliation: receipt-level null or unclear coding is conservative claim-level coding. Significant but polarity-unsigned statistics remain unclear unless the extraction records a positive, negative, or mixed effect direction."]}