{"publication_id":"a333cf41-09e0-46b6-8b35-0a83469ca23b","traces":[{"claim_id":"claim_1","claim":"Telomere length emerges as a dualistic biomarker where elongation simultaneously lowers cardiovascular risk but elevates cancer susceptibility, with the magnitude of these effects critically modulated by genetic variants, measurement precision, and disease-specific contexts like pulmonary fibrosis.","candidate_sources":[{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"**Topic:** `telomere`","doi":null,"url":null},{"study":"**Author:** Dom Lynch","doi":null,"url":null},{"study":"**ORCID:** _not configured_","doi":null,"url":null}]},{"claim_id":"claim_2","claim":"Known / obvious (do not republish): Telomere length shortens with age; Shorter telomeres are generally associated with higher mortality risk; Telomere length is influenced by genetic factors","candidate_sources":[{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"**Topic:** `telomere`","doi":null,"url":null},{"study":"**Author:** Dom Lynch","doi":null,"url":null},{"study":"**ORCID:** _not configured_","doi":null,"url":null}]},{"claim_id":"claim_3","claim":"Real tension: Fact 1 shows genetically determined longer telomere length lowers coronary heart disease risk, while facts 4 and 7 indicate it raises cancer risk, creating a therapeutic dilemma.","candidate_sources":[{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"**Topic:** `telomere`","doi":null,"url":null},{"study":"**Author:** Dom Lynch","doi":null,"url":null},{"study":"**ORCID:** _not configured_","doi":null,"url":null}]},{"claim_id":"claim_4","claim":"`fact_id=109012` (`A_core`) — Genetically determined longer telomere length was associated with lowered risk of coronary heart disease (CHD; OR = 0.95, 95% CI: 0.92-0.98) DOI `10.1111/acel.13017`","candidate_sources":[{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"**Topic:** `telomere`","doi":null,"url":null},{"study":"**Author:** Dom Lynch","doi":null,"url":null},{"study":"**ORCID:** _not configured_","doi":null,"url":null}]},{"claim_id":"claim_5","claim":"`fact_id=109013` (`A_core`) — but raised risk of cancer (OR = 1.11, 95% CI: 1.06-1.16) DOI `10.1111/acel.13017`","candidate_sources":[{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"**Topic:** `telomere`","doi":null,"url":null},{"study":"**Author:** Dom Lynch","doi":null,"url":null},{"study":"**ORCID:** _not configured_","doi":null,"url":null}]},{"claim_id":"claim_6","claim":"_No A_core/B_context counter-evidence found in this run; treat this as a single-direction signal until a broader receipt expansion finds a real opposing fact._","candidate_sources":[{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"**Topic:** `telomere`","doi":null,"url":null},{"study":"**Author:** Dom Lynch","doi":null,"url":null},{"study":"**ORCID:** _not configured_","doi":null,"url":null}]},{"claim_id":"claim_7","claim":"Genetically determined longer telomere length was associated with lowered risk of coronary heart disease (CHD; OR = 0.95, 95% CI: 0.92-0.98) _(alpha cues: translation_context)_","candidate_sources":[{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"**Topic:** `telomere`","doi":null,"url":null},{"study":"**Author:** Dom Lynch","doi":null,"url":null},{"study":"**ORCID:** _not configured_","doi":null,"url":null}]},{"claim_id":"claim_8","claim":"Suggested citation:** Dom Lynch. (2026). The Telomere Length Paradox: Quantifying Trade-offs Between Cardioprotection and Carcinogenesis Across Subgroups. ReseaRka Evidence Index. Version 1.0.","candidate_sources":[{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"**Topic:** `telomere`","doi":null,"url":null},{"study":"**Author:** Dom Lynch","doi":null,"url":null},{"study":"**ORCID:** _not configured_","doi":null,"url":null}]},{"claim_id":"claim_9","claim":"Priority note:** This memo records the first published framing, source bundle, and evidence receipts for this run. Reuse should cite the canonical version.","candidate_sources":[{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"**Topic:** `telomere`","doi":null,"url":null},{"study":"**Author:** Dom Lynch","doi":null,"url":null},{"study":"**ORCID:** _not configured_","doi":null,"url":null}]}]}