{"publication_id":"a90fdec9-309c-4368-bfc1-496e3ccf202f","content_hash":"sha256:e3f90e3768ad811fec9d22947b2c7e1b11bbe799a5bb1e186facda3e350707ce","nodes":[{"id":"a90fdec9-309c-4368-bfc1-496e3ccf202f","type":"publication","title":"Resistance training as a countermeasure to caloric restriction-induced lean mass loss: evidence from obese elderly and heart failure patients"},{"id":"claim_1","type":"claim","text":"The direct receipts support a narrow working claim: RT reduced 93.5% of CR-induced LBM loss; change in strength/LBM ratio tended to be different (p = 0.07) following CRRT (20.9 ± 23.1%) and CR (−7.5 ± 9.9%). The context receipts provide source breadth and boundary checks, not independent confirmation of the lead claim."},{"id":"claim_2","type":"claim","text":"Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication."},{"id":"claim_3","type":"claim","text":"Real tension: the useful signal is narrower than the topic label. The lead receipts support the core claim, while the added A/B context receipts define where that claim may generalize, fail, or need a separate extraction."},{"id":"claim_4","type":"claim","text":"`fact_id=162990` (`A_core`) — 30% CR in young male mice decreased fat mass and improved glucose tolerance and insulin sensitivity doi=10.7554/elife.88080"},{"id":"claim_5","type":"claim","text":"_Boundary evidence only; these receipts broaden source context but do not independently prove the lead claim._"},{"id":"source_1","type":"source","study":"Resistance Training Prevents Muscle Loss Induced by Caloric Restriction in Obese Elderly Individuals: A Systematic Review and Meta-Analysis","year":2018,"doi":"10.3390/nu10040423","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_2","type":"source","study":"Effects of Time-Restricted Feeding and Ramadan Fasting on Body Weight, Body Composition, Glucose Responses, and Insulin Resistance: A Systematic Review of Randomized Controlled Trials","year":2022,"doi":"10.3390/nu14224778","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_3","type":"source","study":"Type 2 Diabetes Remission and Lifestyle Medicine: A Position Statement From the American College of Lifestyle Medicine","year":2020,"doi":"10.1177/1559827620930962","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_4","type":"source","study":"Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice","year":2022,"doi":"10.1126/science.abk0297","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_5","type":"source","study":"The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent","year":2023,"doi":"10.7554/elife.88080","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_6","type":"source","study":"Systemic proteome adaptions to 7-day complete caloric restriction in humans","year":2024,"doi":"10.1038/s42255-024-01008-9","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_7","type":"source","study":"Dietary restriction impacts health and lifespan of genetically diverse mice","year":2024,"doi":"10.1038/s41586-024-08026-3","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"}],"edges":[{"from":"a90fdec9-309c-4368-bfc1-496e3ccf202f","to":"claim_1","type":"contains_claim"},{"from":"a90fdec9-309c-4368-bfc1-496e3ccf202f","to":"claim_2","type":"contains_claim"},{"from":"a90fdec9-309c-4368-bfc1-496e3ccf202f","to":"claim_3","type":"contains_claim"},{"from":"a90fdec9-309c-4368-bfc1-496e3ccf202f","to":"claim_4","type":"contains_claim"},{"from":"a90fdec9-309c-4368-bfc1-496e3ccf202f","to":"claim_5","type":"contains_claim"}],"screening":{"identified":7,"screened":7,"excluded":0,"included":7,"included_or_retained":7,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"7 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]}}