{"publication_id":"b64067ab-fff7-4920-b478-43d193aadc87","traces":[{"claim_id":"claim_1","claim":"resveratrol / exercise does not carry one stable direction across the two receipts; the supported alpha is an endpoint- and setting-bounded comparison rather than a universal benefit or harm claim.","citation_support":[],"candidate_sources":[{"study":"Improvements in skeletal muscle strength and cardiac function induced by resveratrol during exercise training contribute to enhanced exercise performance in rats","year":2012,"doi":"10.1113/jphysiol.2012.230490","url":"https://www.semanticscholar.org/paper/55611be306e3abdce30150fde45b4fc327435317","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary","excerpt":"Improvements in skeletal muscle strength and cardiac function induced by resveratrol during exercise training contribute to enhanced exercise performance in rats","source_id":"source_1","support_kind":"candidate_source_row"},{"study":"Exercise training, but not resveratrol, improves metabolic and inflammatory status in skeletal muscle of aged men","year":2014,"doi":"10.1113/jphysiol.2013.270256","url":"https://doi.org/10.1113/jphysiol.2013.270256","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary","excerpt":"The aim was to investigate the metabolic and anti-inflammatory effects of resveratrol alone and when combined with exercise training in skeletal muscle of aged human subjects. Healthy, physically inactive men (60-72 years old) were randomized to either 8 weeks of daily intake of 250 mg resveratrol or placebo or to 8 weeks of high-intensity exercise training with 250 mg resveratrol or placebo. Before and after the interventions, resting blood samples and muscle biopsies were obtained and a one-legged knee-extensor endurance exercise test was performed. Exercise training increased skeletal muscle peroxisome proliferator-activated receptor-γ co-activator-1α mRNA ~1.5-fold, cytochrome c protein ~1.3-fold, cytochrome c oxidase I protein ~1.5-fold, citrate synthase activity ~1.3-fold, 3-hydroxyacyl-CoA dehydrogenase activity ~1.3-fold, inhibitor of κB-α and inhibitor of κB-β protein content ~1","source_id":"source_2","support_kind":"candidate_source_row"}]},{"claim_id":"claim_2","claim":"One-sentence alpha:** resveratrol / exercise does not carry one stable direction across the two receipts; the supported alpha is an endpoint- and setting-bounded comparison rather than a universal benefit or harm claim.","citation_support":[],"candidate_sources":[{"study":"Improvements in skeletal muscle strength and cardiac function induced by resveratrol during exercise training contribute to enhanced exercise performance in rats","year":2012,"doi":"10.1113/jphysiol.2012.230490","url":"https://www.semanticscholar.org/paper/55611be306e3abdce30150fde45b4fc327435317","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary","excerpt":"Improvements in skeletal muscle strength and cardiac function induced by resveratrol during exercise training contribute to enhanced exercise performance in rats","source_id":"source_1","support_kind":"candidate_source_row"},{"study":"Exercise training, but not resveratrol, improves metabolic and inflammatory status in skeletal muscle of aged men","year":2014,"doi":"10.1113/jphysiol.2013.270256","url":"https://doi.org/10.1113/jphysiol.2013.270256","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary","excerpt":"The aim was to investigate the metabolic and anti-inflammatory effects of resveratrol alone and when combined with exercise training in skeletal muscle of aged human subjects. Healthy, physically inactive men (60-72 years old) were randomized to either 8 weeks of daily intake of 250 mg resveratrol or placebo or to 8 weeks of high-intensity exercise training with 250 mg resveratrol or placebo. Before and after the interventions, resting blood samples and muscle biopsies were obtained and a one-legged knee-extensor endurance exercise test was performed. Exercise training increased skeletal muscle peroxisome proliferator-activated receptor-γ co-activator-1α mRNA ~1.5-fold, cytochrome c protein ~1.3-fold, cytochrome c oxidase I protein ~1.5-fold, citrate synthase activity ~1.3-fold, 3-hydroxyacyl-CoA dehydrogenase activity ~1.3-fold, inhibitor of κB-α and inhibitor of κB-β protein content ~1","source_id":"source_2","support_kind":"candidate_source_row"}]},{"claim_id":"claim_3","claim":"Synthesis:** Receipt 1 reports Improvements in skeletal muscle strength and cardiac function induced by resveratrol during exercise training contribute to enhanced exercise performance in rats in an animal model. Receipt 2 reports Exercise training, but not resveratrol, improves metabolic and inflammatory status in skeletal muscle of aged men; excerpt: Exercise training increased skeletal muscle peroxisome proliferator-activated receptor-γ co-activator-1α mRNA ~1.5-fold, cytochrome c protein ~1.3-fold, cytochrome c oxidase I protein ~1.5-fold, citrate synthase activity ~1.3-fold, 3-hydrox in a human study. The comparison is bounded to resveratrol / exercise, and should not be read as advice, settled science, or a broad class claim.","citation_support":[],"candidate_sources":[{"study":"Improvements in skeletal muscle strength and cardiac function induced by resveratrol during exercise training contribute to enhanced exercise performance in rats","year":2012,"doi":"10.1113/jphysiol.2012.230490","url":"https://www.semanticscholar.org/paper/55611be306e3abdce30150fde45b4fc327435317","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary","excerpt":"Improvements in skeletal muscle strength and cardiac function induced by resveratrol during exercise training contribute to enhanced exercise performance in rats","source_id":"source_1","support_kind":"candidate_source_row"},{"study":"Exercise training, but not resveratrol, improves metabolic and inflammatory status in skeletal muscle of aged men","year":2014,"doi":"10.1113/jphysiol.2013.270256","url":"https://doi.org/10.1113/jphysiol.2013.270256","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary","excerpt":"The aim was to investigate the metabolic and anti-inflammatory effects of resveratrol alone and when combined with exercise training in skeletal muscle of aged human subjects. Healthy, physically inactive men (60-72 years old) were randomized to either 8 weeks of daily intake of 250 mg resveratrol or placebo or to 8 weeks of high-intensity exercise training with 250 mg resveratrol or placebo. Before and after the interventions, resting blood samples and muscle biopsies were obtained and a one-legged knee-extensor endurance exercise test was performed. Exercise training increased skeletal muscle peroxisome proliferator-activated receptor-γ co-activator-1α mRNA ~1.5-fold, cytochrome c protein ~1.3-fold, cytochrome c oxidase I protein ~1.5-fold, citrate synthase activity ~1.3-fold, 3-hydroxyacyl-CoA dehydrogenase activity ~1.3-fold, inhibitor of κB-α and inhibitor of κB-β protein content ~1","source_id":"source_2","support_kind":"candidate_source_row"}]},{"claim_id":"claim_4","claim":"Interpretation:** The supported claim is not universal failure; it is that the Receipt 1 signal does not automatically transfer to the Receipt 2 population, modality, and endpoint bundle.","citation_support":[],"candidate_sources":[{"study":"Improvements in skeletal muscle strength and cardiac function induced by resveratrol during exercise training contribute to enhanced exercise performance in rats","year":2012,"doi":"10.1113/jphysiol.2012.230490","url":"https://www.semanticscholar.org/paper/55611be306e3abdce30150fde45b4fc327435317","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary","excerpt":"Improvements in skeletal muscle strength and cardiac function induced by resveratrol during exercise training contribute to enhanced exercise performance in rats","source_id":"source_1","support_kind":"candidate_source_row"},{"study":"Exercise training, but not resveratrol, improves metabolic and inflammatory status in skeletal muscle of aged men","year":2014,"doi":"10.1113/jphysiol.2013.270256","url":"https://doi.org/10.1113/jphysiol.2013.270256","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary","excerpt":"The aim was to investigate the metabolic and anti-inflammatory effects of resveratrol alone and when combined with exercise training in skeletal muscle of aged human subjects. Healthy, physically inactive men (60-72 years old) were randomized to either 8 weeks of daily intake of 250 mg resveratrol or placebo or to 8 weeks of high-intensity exercise training with 250 mg resveratrol or placebo. Before and after the interventions, resting blood samples and muscle biopsies were obtained and a one-legged knee-extensor endurance exercise test was performed. Exercise training increased skeletal muscle peroxisome proliferator-activated receptor-γ co-activator-1α mRNA ~1.5-fold, cytochrome c protein ~1.3-fold, cytochrome c oxidase I protein ~1.5-fold, citrate synthase activity ~1.3-fold, 3-hydroxyacyl-CoA dehydrogenase activity ~1.3-fold, inhibitor of κB-α and inhibitor of κB-β protein content ~1","source_id":"source_2","support_kind":"candidate_source_row"}]},{"claim_id":"claim_5","claim":"Evidence gap:** The missing study is one matched design with the same population, protocol, dose, duration, and endpoint.","citation_support":[],"candidate_sources":[{"study":"Improvements in skeletal muscle strength and cardiac function induced by resveratrol during exercise training contribute to enhanced exercise performance in rats","year":2012,"doi":"10.1113/jphysiol.2012.230490","url":"https://www.semanticscholar.org/paper/55611be306e3abdce30150fde45b4fc327435317","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary","excerpt":"Improvements in skeletal muscle strength and cardiac function induced by resveratrol during exercise training contribute to enhanced exercise performance in rats","source_id":"source_1","support_kind":"candidate_source_row"},{"study":"Exercise training, but not resveratrol, improves metabolic and inflammatory status in skeletal muscle of aged men","year":2014,"doi":"10.1113/jphysiol.2013.270256","url":"https://doi.org/10.1113/jphysiol.2013.270256","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary","excerpt":"The aim was to investigate the metabolic and anti-inflammatory effects of resveratrol alone and when combined with exercise training in skeletal muscle of aged human subjects. Healthy, physically inactive men (60-72 years old) were randomized to either 8 weeks of daily intake of 250 mg resveratrol or placebo or to 8 weeks of high-intensity exercise training with 250 mg resveratrol or placebo. Before and after the interventions, resting blood samples and muscle biopsies were obtained and a one-legged knee-extensor endurance exercise test was performed. Exercise training increased skeletal muscle peroxisome proliferator-activated receptor-γ co-activator-1α mRNA ~1.5-fold, cytochrome c protein ~1.3-fold, cytochrome c oxidase I protein ~1.5-fold, citrate synthase activity ~1.3-fold, 3-hydroxyacyl-CoA dehydrogenase activity ~1.3-fold, inhibitor of κB-α and inhibitor of κB-β protein content ~1","source_id":"source_2","support_kind":"candidate_source_row"}]}]}