{"publication_id":"b64e5dda-0774-44b5-8adf-3bb0219db815","content_hash":"sha256:47280747ae0a51552080f1051ed511940862a41d5aea8aa264aa13a75b707475","nodes":[{"id":"b64e5dda-0774-44b5-8adf-3bb0219db815","type":"publication","title":"Alpha memo: taurine supplementation"},{"id":"claim_1","type":"claim","text":"Receipt 1 suggests taurine supplementation can blunt a cardio-metabolic risk factor (triglycerides) in high-caloric-fed Wistar rats, while Receipt 2 reframes taurine not as a one-way aid but as a biomarker whose deficiency may signal ageing, making the same molecule read as intervention in one context and as readout in another."},{"id":"claim_2","type":"claim","text":"One-sentence alpha:** Receipt 1 suggests taurine supplementation can blunt a cardio-metabolic risk factor (triglycerides) in high-caloric-fed Wistar rats, while Receipt 2 reframes taurine not as a one-way aid but as a biomarker whose deficiency may signal ageing, making the same molecule read as intervention in one context and as readout in another."},{"id":"claim_3","type":"claim","text":"Receipt 1:** Effects of physical exercise and taurine supplementation on cardio‐metabolic risk factors in high caloric‐fed rats (2012) — in male Wistar rats on a 4-week high-caloric diet followed by 5 weeks of treadmill training (20 m/min, 60 min, 3×/week) and/or 2% taurine in drinking water, exercise or taurine per se reduced triglycerides, alongside an ~45% performance gain in trained groups."},{"id":"source_1","type":"source","study":"Effects of physical exercise and taurine supplementation on cardio‐metabolic risk factors in high caloric‐fed rats","year":2012,"doi":"10.1096/fasebj.26.1_supplement.1142.41","url":"https://doi.org/10.1096/fasebj.26.1_supplement.1142.41","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary","excerpt":"To evaluate the effects of exercise sessions, three times a week, and taurine supplementation on blood concentration of glucose, triglycerides and TBARS. Twenty male Wistar rats were divided: sedentary (SD); sedentary taking taurine (SD+TAU); trained (TR) and trained taking taurine (TR+TAU). Exercise training and taurine supplementation (drinking water at 2%) started after four weeks of high caloric diet consumption and was carried out for further five weeks. Animals exercised at a treadmill (20 m/min), 60 min, 3 days/week. Insulin tolerance test (ITT) was done and K ITT calculated. After an overnight fasting, rats were sacrificed and glucose, triglycerides, and TBARS concentrations were measured by commercial kits. Data were analyzed by two‐way ANOVA (p<0.05). Exercise protocol improved performance about 45% in booth trained groups. Exercise or taurine, per se , reduced triglycerides (4"},{"id":"source_2","type":"source","study":"Taurine as a biomarker for aging: A new avenue for translational research","year":2023,"doi":"10.1016/j.abst.2023.10.002","url":"https://doi.org/10.1016/j.abst.2023.10.002","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary","excerpt":"The physiologic and irreversible process of ageing is accompanied by a wide range of structural and functional shifts at multiple different levels. It is also suggested that variations in the blood concentrations of metabolites, hormones, and micronutrients may play a role in the ageing process. Recently, Singh et al. 1,2 investigated a study on Taurine shortage as a driver and biomarker of ageing and its impact on a healthy lifespan. 2 They further proposed that functional abnormalities in numerous organs associated with age-related illnesses have been linked to early-life Taurine insufficiency. Taurine deficiency in the elderly and the possible benefits of Taurine supplements One of the reasons for decreasing Taurine concentration is the loss of endogenous synthesis, which may contribute to the decrease in Taurine levels seen in the elderly. While it was previously believed that the li"}],"edges":[{"from":"b64e5dda-0774-44b5-8adf-3bb0219db815","to":"claim_1","type":"contains_claim"},{"from":"b64e5dda-0774-44b5-8adf-3bb0219db815","to":"claim_2","type":"contains_claim"},{"from":"b64e5dda-0774-44b5-8adf-3bb0219db815","to":"claim_3","type":"contains_claim"}],"screening":{"identified":2,"screened":2,"excluded":0,"included":2,"included_or_retained":2,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"2 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]}}