{"publication_id":"d2507e5a-e8e6-4a30-aa39-33d2478faccc","traces":[{"claim_id":"claim_1","claim":"The direct receipts support a narrow working claim: Compared with control, exercise alone reduced hs-CRP [-30.2%; 95% CI, -50.3, -1.0]; exercise alone reduced hs-CRP and IL6 (-30.9%; 95% CI, -47.3, -9.5). The context receipts provide source breadth and boundary checks, not independent confirmation of the lead claim.","candidate_sources":[{"study":"Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial","doi":"10.1158/1940-6207.capr-20-0188","url":null},{"study":"Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin","doi":"10.1152/ajpendo.00600.2013","url":null},{"study":"Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development","doi":"10.1158/0008-5472.can-16-3125","url":null},{"study":"Exercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years","doi":"10.1161/hypertensionaha.114.03510","url":null},{"study":"Effects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial","doi":"10.1158/1055-9965.epi-13-0337","url":null}]},{"claim_id":"claim_2","claim":"The useful signal is narrower than the topic label: the lead receipts support the core claim, while the added A/B context receipts define where that claim may generalize, fail, or need a separate extraction.","candidate_sources":[{"study":"Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial","doi":"10.1158/1940-6207.capr-20-0188","url":null},{"study":"Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin","doi":"10.1152/ajpendo.00600.2013","url":null},{"study":"Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development","doi":"10.1158/0008-5472.can-16-3125","url":null},{"study":"Exercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years","doi":"10.1161/hypertensionaha.114.03510","url":null},{"study":"Effects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial","doi":"10.1158/1055-9965.epi-13-0337","url":null}]},{"claim_id":"claim_3","claim":"`fact_id=12572` (`A_core`) — Mixed-muscle protein fractional synthetic rate increased by 42% at 3 h postexercise and 69% at 24 h postexercise in CON. DOI `10.1152/ajpendo.00600.2013`","candidate_sources":[{"study":"Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial","doi":"10.1158/1940-6207.capr-20-0188","url":null},{"study":"Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin","doi":"10.1152/ajpendo.00600.2013","url":null},{"study":"Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development","doi":"10.1158/0008-5472.can-16-3125","url":null},{"study":"Exercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years","doi":"10.1161/hypertensionaha.114.03510","url":null},{"study":"Effects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial","doi":"10.1158/1055-9965.epi-13-0337","url":null}]},{"claim_id":"claim_4","claim":"`fact_id=12544` (`A_core`) — Mortality risk was 11% lower (hazard ratio, 0.89; 95% confidence interval, 0.86-0.93; P<0.001) for every 1-MET increase in exercise capacity. DOI `10.1161/hypertensionaha.114.03510`","candidate_sources":[{"study":"Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial","doi":"10.1158/1940-6207.capr-20-0188","url":null},{"study":"Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin","doi":"10.1152/ajpendo.00600.2013","url":null},{"study":"Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development","doi":"10.1158/0008-5472.can-16-3125","url":null},{"study":"Exercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years","doi":"10.1161/hypertensionaha.114.03510","url":null},{"study":"Effects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial","doi":"10.1158/1055-9965.epi-13-0337","url":null}]},{"claim_id":"claim_5","claim":"`fact_id=30392` (`A_core`) — IGF-I/IGFBP-3 ratio increased significantly in the diet + exercise group (+5.4%, P < 0.01) compared with control. DOI `10.1158/1055-9965.epi-13-0337`","candidate_sources":[{"study":"Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial","doi":"10.1158/1940-6207.capr-20-0188","url":null},{"study":"Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin","doi":"10.1152/ajpendo.00600.2013","url":null},{"study":"Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development","doi":"10.1158/0008-5472.can-16-3125","url":null},{"study":"Exercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years","doi":"10.1161/hypertensionaha.114.03510","url":null},{"study":"Effects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial","doi":"10.1158/1055-9965.epi-13-0337","url":null}]},{"claim_id":"claim_6","claim":"_No A_core/B_context counter-evidence found in this run; treat this as a single-direction signal until a broader receipt expansion finds a real opposing fact._","candidate_sources":[{"study":"Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial","doi":"10.1158/1940-6207.capr-20-0188","url":null},{"study":"Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin","doi":"10.1152/ajpendo.00600.2013","url":null},{"study":"Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development","doi":"10.1158/0008-5472.can-16-3125","url":null},{"study":"Exercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years","doi":"10.1161/hypertensionaha.114.03510","url":null},{"study":"Effects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial","doi":"10.1158/1055-9965.epi-13-0337","url":null}]},{"claim_id":"claim_7","claim":"Suggested citation:** Dom Lynch. (2026). Exercise: single-source lead signal with broader context receipts. ReseaRka Evidence Index. Version 1.0.","candidate_sources":[{"study":"Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial","doi":"10.1158/1940-6207.capr-20-0188","url":null},{"study":"Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin","doi":"10.1152/ajpendo.00600.2013","url":null},{"study":"Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development","doi":"10.1158/0008-5472.can-16-3125","url":null},{"study":"Exercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years","doi":"10.1161/hypertensionaha.114.03510","url":null},{"study":"Effects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial","doi":"10.1158/1055-9965.epi-13-0337","url":null}]},{"claim_id":"claim_8","claim":"Priority note:** This memo records the first published framing, source bundle, and evidence receipts for this run. Reuse should cite the canonical version.","candidate_sources":[{"study":"Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial","doi":"10.1158/1940-6207.capr-20-0188","url":null},{"study":"Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin","doi":"10.1152/ajpendo.00600.2013","url":null},{"study":"Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development","doi":"10.1158/0008-5472.can-16-3125","url":null},{"study":"Exercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years","doi":"10.1161/hypertensionaha.114.03510","url":null},{"study":"Effects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial","doi":"10.1158/1055-9965.epi-13-0337","url":null}]}]}