{"publication_id":"d2507e5a-e8e6-4a30-aa39-33d2478faccc","content_hash":"sha256:e73dcf03405a9629fbf28484081b12efa9de86d23326637941879a032f3d0ac7","nodes":[{"id":"d2507e5a-e8e6-4a30-aa39-33d2478faccc","type":"publication","title":"Exercise: single-source lead signal with broader context receipts"},{"id":"claim_1","type":"claim","text":"The direct receipts support a narrow working claim: Compared with control, exercise alone reduced hs-CRP [-30.2%; 95% CI, -50.3, -1.0]; exercise alone reduced hs-CRP and IL6 (-30.9%; 95% CI, -47.3, -9.5). The context receipts provide source breadth and boundary checks, not independent confirmation of the lead claim."},{"id":"claim_2","type":"claim","text":"The useful signal is narrower than the topic label: the lead receipts support the core claim, while the added A/B context receipts define where that claim may generalize, fail, or need a separate extraction."},{"id":"claim_3","type":"claim","text":"`fact_id=12572` (`A_core`) — Mixed-muscle protein fractional synthetic rate increased by 42% at 3 h postexercise and 69% at 24 h postexercise in CON. DOI `10.1152/ajpendo.00600.2013`"},{"id":"claim_4","type":"claim","text":"`fact_id=12544` (`A_core`) — Mortality risk was 11% lower (hazard ratio, 0.89; 95% confidence interval, 0.86-0.93; P<0.001) for every 1-MET increase in exercise capacity. DOI `10.1161/hypertensionaha.114.03510`"},{"id":"claim_5","type":"claim","text":"`fact_id=30392` (`A_core`) — IGF-I/IGFBP-3 ratio increased significantly in the diet + exercise group (+5.4%, P < 0.01) compared with control. DOI `10.1158/1055-9965.epi-13-0337`"},{"id":"claim_6","type":"claim","text":"_No A_core/B_context counter-evidence found in this run; treat this as a single-direction signal until a broader receipt expansion finds a real opposing fact._"},{"id":"claim_7","type":"claim","text":"Suggested citation:** Dom Lynch. (2026). Exercise: single-source lead signal with broader context receipts. ReseaRka Evidence Index. Version 1.0."},{"id":"claim_8","type":"claim","text":"Priority note:** This memo records the first published framing, source bundle, and evidence receipts for this run. Reuse should cite the canonical version."},{"id":"source_1","type":"source","study":"Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial","year":2020,"doi":"10.1158/1940-6207.capr-20-0188","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_2","type":"source","study":"Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin","year":2014,"doi":"10.1152/ajpendo.00600.2013","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_3","type":"source","study":"Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development","year":2017,"doi":"10.1158/0008-5472.can-16-3125","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_4","type":"source","study":"Exercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years","year":2014,"doi":"10.1161/hypertensionaha.114.03510","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_5","type":"source","study":"Effects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial","year":2013,"doi":"10.1158/1055-9965.epi-13-0337","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_6","type":"source","study":"**Topic:** `exercise`","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_7","type":"source","study":"**Author:** Dom Lynch","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_8","type":"source","study":"**ORCID:** _not configured_","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_9","type":"source","study":"**Version:** 1.0","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_10","type":"source","study":"**License:** CC BY-NC 4.0","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_11","type":"source","study":"**Canonical URL:** _not assigned_","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_12","type":"source","study":"**Suggested citation:** Dom Lynch. (2026). Exercise: single-source lead signal with broader context receipts. ReseaRka Evidence Index. Version 1.0.","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_13","type":"source","study":"**Run bundle SHA-256:** `fe487b28cd8297287f8c8def5605a5aac25b0a1723c07436f22dfdaea7dc6374`","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_14","type":"source","study":"**Memo SHA-256:** `12c36db3312628e59f58153f26a3a4e818cb983d57e130624eff79bc4b43b487`","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_15","type":"source","study":"**Priority note:** This memo records the first published framing, source bundle, and evidence receipts for this run. Reuse should cite the canonical version.","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"}],"edges":[{"from":"d2507e5a-e8e6-4a30-aa39-33d2478faccc","to":"claim_1","type":"contains_claim"},{"from":"d2507e5a-e8e6-4a30-aa39-33d2478faccc","to":"claim_2","type":"contains_claim"},{"from":"d2507e5a-e8e6-4a30-aa39-33d2478faccc","to":"claim_3","type":"contains_claim"},{"from":"d2507e5a-e8e6-4a30-aa39-33d2478faccc","to":"claim_4","type":"contains_claim"},{"from":"d2507e5a-e8e6-4a30-aa39-33d2478faccc","to":"claim_5","type":"contains_claim"},{"from":"d2507e5a-e8e6-4a30-aa39-33d2478faccc","to":"claim_6","type":"contains_claim"},{"from":"d2507e5a-e8e6-4a30-aa39-33d2478faccc","to":"claim_7","type":"contains_claim"},{"from":"d2507e5a-e8e6-4a30-aa39-33d2478faccc","to":"claim_8","type":"contains_claim"}],"screening":{"identified":5,"screened":5,"excluded":0,"included":5,"included_or_retained":5,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]}}